Hypochlorous acid has been shown to play a significant role in the treatment of corneal bacteria, especially in the treatment of bacterial corneal ulcer. For example, a study by the Ophthalmology department of the Affiliated Hospital of Xuzhou Medical University showed that 0.01% hypochlorous acid local eye drops could significantly accelerate the healing of bacterial corneal ulcers without serious complications. In addition, HOCL also shows good results in the treatment of bacterial and viral conjunctivitis, and can effectively kill a variety of bacteria and viruses, including MRSA and HIV.
In the treatment of burn wounds, HOCL showed significant antibacterial and anti-infection effects as well. Studies have shown that hypochlorous acid can reduce histamine, leukotriene B4 (LTB4) activity, and interleukin, thereby reducing itch in the body, and has a significant dewound and anti-infection effect on degree I and second degree burns. In addition, hypochlorous acid can effectively remove bacterial biofilms and promote wound healing when treating chronic wounds.
HOCL is effective in the treatment of corneal bacteria and burn wound, which can accelerate the healing speed, reduce complications, and has good safety.
What is the specific mechanism of hypochlorous acid in the treatment of corneal bacteria?
It is mainly reflected in the following aspects:
Antibacterial action: Hypochlorous acid is a highly effective antibacterial agent that can effectively kill a variety of bacteria and viruses, including MRSA and HIV. In the treatment of bacterial corneal ulcers, 0.01% hypochlorous acid eye drops have been shown to accelerate the healing of ulcers without serious complications.
Reduce the expression of inflammatory factors: hypochlorous acid has good skin tolerance and safety, and can reduce the expression of histamine, matrix metalloproteinase (MMP) -9, interleukin (IL) -1, IL-6 and other inflammatory factors in damaged skin. This mechanism of action helps to reduce the inflammatory response of the eye, thereby promoting the healing of the cornea.
Reduce the amount of bacteria carried: hypochlorous acid solution can reduce the amount of bacteria carried on the skin of the eye, which helps control the further spread of infection.
When hypochlorous acid is used to treat burn wounds, what is the difference in debridement effect for different degrees of burn (degree I and Degree II)?
The debridement effect of hypochlorous acid in treating burn wound is different in different degree of burn (I degree and II degree). The bactericidal effect of biological hypochloric acid on deep degree II burn wounds and infected wounds was better than that of normal saline, and the number of bacterial colonies on deep degree II burn wounds and infected wounds was significantly reduced after use, and the effect was time-dependent. However, the specific debridement effect of I degree burns is not directly mentioned in the materials I searched.
What are the detailed reports or studies on the safety and side effects of hypochlorous acid in the treatment of burn wounds?
Hypochlorous acid (HClO/HOCL) has certain safety and effectiveness as a disinfectant in the treatment of burn wounds, but its side effects and potential risks can not be ignored.
Safety:
- Therapeutic effect: Hypochlorous acid solution is widely used in clinical treatment of diabetic foot ulcers, venous ulcers of lower limbs, surgical wounds, chronic wounds, mixed wounds and infectious trauma wounds, including burn wounds. Through its fast and efficient bactericidal ability, it can safely and effectively prevent wound infection and accelerate wound healing.
- No antibiotic resistance: The use of hypochlorous acid solutions does not cause further antibiotic resistance problems and does not cause adverse side effects.
- In vitro safety assessment: Commercial washings and dressings containing HClO have been proven to have good therapeutic effects on diabetic foot infection, lower limb ulcer, burn infection, etc.
Side effects and potential risks
Cytotoxicity: In laboratory studies, a full concentration (0.5%) of Dakin’s® solution was cytotoxic to fibroblasts, which may delay wound healing. In addition, hypochlorite anion has obvious cytotoxicity at high concentrations.
Respiratory irritation: Hypochlorous acid, when used in normal concentrations, can irritate the respiratory tract, causing mild symptoms such as respiratory burning, tingling, nasopharyngeal discomfort, mild cough, and dizziness. Exposure to a higher concentration of hypochlorous acid solution may cause more serious irritation and even toxic reactions.
Other health effects: Sodium hypochlorite (NaClO) has an anesthetic effect and is harmful to the heart, liver, and kidneys. Symptoms of acute poisoning include headache, dizziness, nausea, etc. In severe cases, respiratory paralysis and liver and kidney damage may occur.
Comprehensive evaluation
Hypochlorous acid has a significant adjuvant therapeutic effect in the treatment of burn wounds, which can effectively prevent infection and accelerate healing. However, it should be used with caution, especially at high concentrations, to avoid cytotoxicity and potential damage to respiratory and internal organs.
What are the results of the comparative study between hypochlorous acid and other antibacterial agents (such as floriprobine) in the treatment of corneal bacteria?
The comparative study on the antibacterial effect of hypochlorous acid (HA) and povidone iodine (PI) in the eye showed that the antibacterial effect of 0.01% biotype hypochlorous acid and 5% povidone iodine applied to the eye surface was compared. The study suggests that hypochlorous acid can be used as an effective alternative antimicrobial agent for patients who cannot tolerate POvidone iodine.
The application of hypochlorous acid in eye care shows that hypochlorous acid has a good effect on the treatment of fungal infection after Boston type 1 artificial cornea surgery. In addition, POvidone-iodine disinfection of conjunctival sac can significantly reduce postoperative complications of cataract infection, and hypochlorous acid solution disinfection can also effectively kill bacteria in conjunctival sac.
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